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Changing Lives Through DNA Genetic Testing
The AGS Blog & Press Releases

Weight Management --An Exercise Prescription Based On Your Genes

[fa icon="calendar"] Oct 20, 2017 5:42:30 PM / by Dr Chan Hoi Chung Samuel

Dr Chan Hoi Chung Samuel

What causes obesity?

Obesity is normally the result of excessive calorie intake, a lack of healthy exercise, or a combination of the two. Sometimes disease or pre-existing conditions can also be a contributing factor. Consuming fewer calories or increasing regular exercise leads to weight loss, but exactly how beneficial these actions are to weight reduction for a particular person depends very much on his/her genetic makeup.

Let's look at how exercise can be used to reduce weight, and how genes play a role in the results:

The best exercise to lose weight is usually a combination of resistance and aerobic exercise. For instance, a safe and effective cornerstone in building a resistance training program involves lifting weight for one to three sets of 10-15 repetitions, making sure to target all major muscle groups.

Scientifically, different genotypes of FTO – a gene correlated with obesity and higher levels of the “hunger-hormone” ghrelin – are associated with different extents of beneficial effects of exercise on weight reduction. Other genes play a role as well: genotypes of metabolism-related genes such as PPARD, CKM, UCP3 etc., can also predict our response to endurance exercise. By analyzing these genes and understanding their effects, in concert with an individual's health goal, the individual can make better exercise choices that best suite their genes. For example, some people may benefit by spending more time doing aerobic exercise, while others may experience more beneficial results from resistance training.

Now lets look at how understanding your genes can help you exercise more safely.

When exercising, safety is also very important, and again, our genes play a role. Chances of various kinds of soft tissue injuries with exercise also differ among individuals. Different genotypes of several genes including GDF5, COL1A1 and COL5A1 are involved in predicting the likelihood of soft tissue injuries. For those people that are considered obese and have genotypes that increase the likelihood of injury, high-risk exercises such as football, basketball, and rugby, should only be done with extreme caution and an awareness of what your body is trying to tell you when you say, "ouch!"

Health and wellness genetic tests can provide insight into your unique genetics and help you work with your genes to accomplish your fitness goals in a safe and effective manner.


Download the free brochure to learn more about the benefits of Health & Wellness DNA testing 


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About AGS

Advanced Genomic Solutions (AGS) empowers patients and physicians to make more informed choices about prescription drugs, nutrition, and exercise. Through advanced genomic technology, AGS improves lives, saves medical expenses and educates patients to be advocates for their health. AGS is the leading expert in integrating Pharmacogenomics and Health & Wellness testing into physician’s practices to provide the best standard of care for their patients. Headquartered in Scottsdale, Arizona and Hong Kong, AGS has successfully launched hundreds of advanced medical products in China, South East Asia and India since 1997. 



Topics: DNA Testing, Diet & Eating, Exercise

Dr Chan Hoi Chung Samuel

Written by Dr Chan Hoi Chung Samuel

Dr Chan Hoi Chung Samuel is a family doctor working in private practice. He got three masters degrees including master of science in endocrinology, master of science in cardiology and master in musculoskeletal medicine and rehabilitation

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